实验室负责人

        李芬芬 博士 特任副研究员

        中国科学技术大学 医学影像中心

研究方向

        纳米探针的设计和合成：合成不同无机纳米材料，如铁氧化物纳米颗粒、二维纳米片、量子点等并对其表面进行修饰；合成脂质体材料及自组装纳米材料用于生物医学应用。

        疾病诊断及治疗：利用合成的纳米探针或纳米药物，采用不同给药方式实现探针或药物在肿瘤及炎症部位的靶向递送，通过磁共振等影像学手段实现疾病早期诊断及治疗。

文章发表

(1) H. X. Wang, W. S. Wang, C. P. Li, A. Xu, B. S. Qiu*, F. F. Li*, W. P. Ding*, Flav7+DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors, Chemical Engineering Journal 428 (2022).

(2)    W. S. Wang, F. F. Li*, S. B. Li, Y. Hu, M. R. Xu, Y. Y. Zhang, M. I. Khan, S. Z. Wang, M. Wu, W. P. Ding*, B. S. Qiu*, M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy, Journal of Material Science & Technology 81 (2021) 77-87.

(3)    Y. Y. Zhang, F. F. Li*, S. N. Ya, Y. Hu, D. B. Zhi, W. S. Wang, M. R. Xu, B. S. Qiu*, W. P. Ding*, An iron oxide nanoparticle-based transdermal nanoplatform for dual-modal imaging-guided chemo-photothermal therapy of superficial tumors, Acta Biomaterialia 130 (2021) 473-484.

(4)    F. F. Li#, T. W. Li#, D. B. Zhi#, P. P. Xu, W. S. Wang, Yi. Hu, Y. Y. Zhang, S. Z. Wang, J. Matula Thomas, J. Beauchamp Norman, W. P. Ding*, L. F. Yan*, B. S. Qiu*, Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy, Biomaterials256 (2020) 120219.

(5) M. R. Xu, Y. Hu, Y. Xiao, Y. Y. Zhang, K. L. Sun, T. Wu, N. Lv, W. S. Wang, W. P. Ding, F. F. Li*, B. S. Qiu*, J. B. Li*, Near-Infrared-Controlled Nanoplatform Exploiting Photothermal Promotion of Peroxidase-like and OXD-like Activities for Potent Antibacterial and Anti-biofilm Therapies, ACS Applied Materials & Interfaces 12(45) (2020) 50260-50274.

(6)    F. F. Li, D. B. Zhi, Y. F. Luo, J. Q. Zhang, X. Nan, Y. J. Zhang, W. Zhou, B. S. Qiu*, L. P. Wen*, G. L. Liang*, Core/shell Fe₃O₄/Gd₂O₃ nanocubes as T₁-T₂ dual modal MRI contrast agents, Nanoscale 8(25) (2016) 12826-12833.

(7)    S. W. Ali, F. A. Mangrio, F. F. Li*, P. Dwivedi, M. U. Rajput, R. Ali, M. I. Khan, W. P. Ding*, R. X. Xu*, Co-delivery of artemether and piperine via core-shell microparticles for enhanced sustained release, Journal of Drug Delivery Science & Technology 63 (2020).