Adoptive immunotherapy such as CAR-T, TIL and NK cell therapy are promising in treating hematological malignancy but are less efficient against solid tumors. A major obstacle is the limited infiltration of adoptively transferred immune cells into the tumor bed. We aim to study the molecular mechanisms underlying the immune exclusion or immune desert phenotype of tumors by in vivo visualization of the T cell trafficking upon transfer. Our ultimate goal is to optimize the current adoptive immunotherapy regimen by improving the infiltration of T cells into “cold” tumors.
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